Reviews: Stem Cells and Niches by Sean Morrison

by Alexey Bersenev on February 21, 2008 · 3 comments

in niche, reviews

Today’s issue of Cell journal is special – collection of stem cell reviews from leading scientists.
I dig Sean Morrison‘s review: Stem Cells and Niches: Mechanisms That Promote Stem Cell Maintenance throughout Life.

Niches are local tissue microenvironments that maintain and regulate stem cells.

Additional stem cells lie dormant, but can be activated at particular life cycle stages, or following injury. These potent agents are controlled within restricted tissue microenvironments known as “niches.” Until recently, niches were a theoretical concept strongly supported by the observation that transplanted stem cells survive and grow only in particular tissue locations. The number of such sites could be saturated, after which transferring additional stem cells provided little or no further engraftment. However, in recent years it has become possible to identify stem cells and niches with increasing precision.

Excellent review! Current complete updated overview of the problem including methodological approaches to study niches.
Highly recommend to read!

Scheme of hematopoietic stem cell niche from review:

Open access to full text

{ 3 comments… read them below or add one }

NJ March 12, 2008 at 6:08 pm

good! I like this one!


Alex March 13, 2008 at 7:24 pm

Other remarkable review from Sean Morrison just came up in online version of Nature Reviews Immunology Uncertainty in the niches that maintain haematopoietic stem cells


Alex April 9, 2008 at 9:54 pm

so mesenchymal/stromal stem cell do not create/participate in any niches? They are in stroma, right? Not restricted to endosteum or vasculature.
Don’t you think it’s 3rd type of niche?
Or am I not right? Maybe they are participate in both niches through CXCR4-SDF1?


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