Twenty years of follow-up among survivors of childhood and young adult acute myeloid leukemia

by Alexey Bersenev on March 11, 2008 · 2 comments

in clinical trials and cases, leukemia

Blogging on Peer-Reviewed ResearchSince 1957, when Don Thomas reported about the first infusion of bone marrow for treatment patients receiving radiation and chemotherapy, more then 50 000 people with hematological disorders were treated worldwide. Bone marrow transplantation (BMT) revolutionized medicine because many kind of childhood and adult leukemias became cured. In the same time chemotherapy of leukemias was significantly improved. Modern conditioning protocols allow treat some forms of leukemias without BMT.

New report, published online in Cancer journal, summarized 20-years results achieved in childhood and young adult acute myeloid leukemia (AML) non-transplantation treatment.

This analysis included 272 5-year AML survivors who participated in the Childhood Cancer Survivor Study ( CCSS). All patients were diagnosed at age 21 years between the years 1970 and 1986, and none underwent stem cell transplantation. Rates of survival, relapse, and late outcomes were analyzed.

Graph of overall survival below (CI = confidence interval):

some results from this giant study:

– The overall survival rate was 97% at 10 years
and 94% at 20 years
– 6 survivors reported 8 recurrences
– The cumulative incidence of recurrent AML was 6.6% at 10 years
and 8.6% at 20 years
– Among those aged 25 years, the age-adjusted marriage rates were similar among survivors and the general US population
– Survivors’ college graduation rates were lower compared with siblings but higher than the general population
– Employment rates were similar between survivors, siblings, and the general population

Cumulative incidence of subsequent malignant neoplasms among 5-year AML survivors:

Great results! Very important report and conclusion:

These analyses demonstrated excellent 10- and 20-year survival rates among children and young adults diagnosed with AML who were treated with chemotherapy with or without RT, but not HSCT, and who survived at least 5 years after diagnosis. Recurrent cancer, second malignancies, and cardiac events were infrequent but exceeded the rates observed in the general population.

Cancer Epub. Mar.7,2008

{ 2 comments… read them below or add one }

JWS March 14, 2008 at 8:35 am

Excellent study, but need to address relapse problems in the future… By removing cancer stem cell??


Alex March 16, 2008 at 9:35 pm

According modern concept of drug-resistant cancer stem cell as reason of relapses – YES!


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