Reviews: Chemokine-mobilized adult stem cells; defining a better hematopoietic graft by Pelus LM & S. Fukuda

by Alexey Bersenev on March 13, 2008 · 0 comments

in reviews

Mobilized hematopoietic stem cells, that is, stem cells induced to exit marrow and traffic to peripheral blood in response to external stimuli, are now the primary source of stem cells for autologous and allogeneic hematopoietic transplantation. The initial observations that hematopoietic progenitor cells (HPC) were found in the blood of patients recovering from chemotherapy lead to the realization that stem cells could be forced to exit marrow where they can be collected by apheresis and used for clinical transplantation

Concept of mobilization implied application of drugs – chemokine agonists and chemokine receptor antagonists which are disrupt interaction hematopoietic stem cell (HSC) with bone marrow niche and caused their release into bloodstream.

This review, prepublished in Leukemia journal, compared efficacy of different mobilizers in terms of HSC number and function (ability to engraft, multilineage differentiation and self-renewal).

I really like all of figures in the review. For example this one is very important and show comparison of functional activity of HSC, mobilized by different drugs in competitive repopulation and serial bone marrow transplantation assay:

Full text of this great review in open access!

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