I’d like to share presentation that I made for journal club on paper: “mTOR Regulation and Therapeutic Rejuvenation of Aging Hematopoietic Stem Cells” published in Science Signaling 2 months ago. This is online version of presentation – without original figures.
The study give us more clue about how aging and stem cells are connected. Can we play with longevity through stem cells?
The current status of our knowledge I’d like to illustrate by quote from Sean Morrison’s review:
On the one hand, the changes in stem cell function that occur during aging would be expected to contribute to age-related morbidity by reducing tissue regenerative capacity. Moreover, the accumulation of genetic damage in stem cells likely contributes to increased cancer incidence during aging (Rossi et al. 2008, Sharpless & DePinho 2007). On the other hand, the effects of aging on fully differentiated cells are likely a major and independent contributor to age-related morbidity, cancer incidence, and degenerative disease. It remains unclear whether the changes that occur in stem cells are a major or minor contributor to age-related morbidity and life span.