This is an annual report of registered clinical trials in cell therapy. Every year I overview some tracked data from international clinical trials databases. You can see 2011 report here.
I tracked clinical trials which fall in definition of cell therapy: administration of living cells in human with therapeutic purpose. I included tissue engineering, cellular gene therapy and devices for cell processing. I tracked all clinical trials which were registered from Jan.1, 2012 to Dec. 31, 2012 in international databases.
Trials, assessing cell therapy for homologous use were excluded from analysis. Examples: (1) hematopoietic cells for recovery of blood formation (in hematological malignancies) or (2) ex vivo expansion of hematopoietic cells for enhancement of engraftment in hematological malignancies.
Hand coding and data collection
“Hand coding” included:
- using multiple key words and phrases
- exclusion of overlaps between search results
- exclusion of duplications between databases
- reading trial description and “coding” the following categories: trial ID, country, phase, status, indication, cell type, donor type, type of sponsorship, name of company-sponsor, study acronym, number of patients in enrollment.
Search key words:
Total number of trials tracked: 226
Number of duplications between databases: 6
All international databases, except NCT, were scanned via WHO Search Portal.
All trials were divided on 2 categories – “academic” and “industry”. The term “academic” combined any monetary support (governments, funds…) other than “company-sponsored” (“industry”). Term “industry” also included companies – collaborators, when sponsorship is not clear from trial description.
I was able to identify 36 different cell types used in clinical trials. All cell types were roughly divided on “stem” and “non-stem”. “Stem” cell types included: embryonic stem cells, mesenchymal stromal cells, hematopoietic stem/ progenitor cells, cardiac stem/ progenitor cells, fetal neural stem cells, CD133+ cells, limbal stem cells, dental pulp stem cells, adipose stromal vascular fraction.
I was able to identify 7 different types of MSC, based on source:
Abbreviations: SC – stem cells; ESC – embryonic stem cells, MSC – mesenchymal stromal cells, HSPC – hematopoietic stem/ progenitor cells, TIL – tumor-infiltrating lymphocytes, DC – dendritic cells, BM – bone marrow, MNC – mononuclear cells, NK – natural killer cells, CIK – cytokine-induced killers, SVF – stromal vascular fraction; EPC – endothelial proogenitor cells; MPB – mobilized peripheral blood.
Cell donor type:
This was a snapshot of data, which I’ve been collecting during the year. More analysis and trends are coming.
You can follow real time updates via @CellTrials
How to cite:
Bersenev Alexey. Cell therapy clinical trials – 2012 report. CellTrials blog. January 8, 2013. Available: http://celltrials.info/2013/01/08/2012-report/