CAR (Chimeric Antigen Receptor)-based cell clinical trials is one of the hottest areas in cell therapy right now. Today, I’d like to share with you a trend for total number of CAR cell trials, registered worldwide. Importantly, I made figures available for free download on FigShare. You can get it in high resolution and use it for your presentations!
10 International public databases (including NCT, EudraCT, UMIN, ChiTCR, ANZCTR…) were screened to identify CAR clinical trials, registered in any period of time until December 31 of 2016. At least 10 combinations of key words were used in search queries (including “cell”, “CAR cell”, “chimeric antigen”, “T cell”, “T cell gene modified”…). Only CAR genetic modification of cells was included. At least 23 parameters were captured manually, if information was available. Validity of captured data was verified by second researcher (CellTrials.org). Overlaps between databases were excluded from analysis. Statistical information was analyzed in MS Exel.
252 unique trials were identified from 2004 to the end of 2016. 11 overlaps between registries were found. The first CAR trial was registered in 2004. 245/252 (97%) of CAR cell trials involved T-cells. In 2016 alone was registered 116 CAR cell trials. About 75% of all registered trials are currently listed as active. 2 listings from 2015 and 5 listings from 2016 were identified as “follow-up studies”, but not actual trials. However, for completeness of the CAR cell data, these listings were also included in CellTrials.org dataset and statistical analysis below.
1. A trend for total number of trials, registered year-to-year (not cumulative data), starting from 2007 (click to enlarge):
How to cite: Bersenev, Alexey (2017): Total number of CAR cell therapy trials listed in databases. figshare. https://doi.org/10.6084/m9.figshare.4628557.v2
2. Phases of registered CAR cell trials (click to enlarge):
Please feel free to download figures, share, embed and cite!
Access raw CAR cell trials data to make your own graphs!